Journal article
Humans lack iGb3 due to the absence of functional iGb3-synthase: Implications for NKT cell development and transplantation
D Christiansen, J Milland, E Mouhtouris, H Vaughan, DG Pellicci, MJ McConville, DI Godfrey, MS Sandrin
Plos Biology | PUBLIC LIBRARY SCIENCE | Published : 2008
Abstract
The glycosphingolipid isoglobotrihexosylceramide, or isogloboside 3 (iGb3), is believed to be critical for natural killer T (NKT) cell development and self-recognition in mice and humans. Furthermore, iGb3 may represent an important obstacle in xenotransplantation, in which this lipid represents the only other form of the major xenoepitope Galα(1,3)Gal. The role of iGb3 in NKT cell development is controversial, particularly with one study that suggested that NKT cell development is normal in mice that were rendered deficient for the enzyme iGb3 synthase (iGb3S). We demonstrate that spliced iGb3S mRNA was not detected after extensive analysis of human tissues, and furthermore, the iGb3S gene ..
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Awarded by Seventh Framework Programme